Ellagic acid | C14H6O8 | CID 5281855 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety . Ellagic Acid Kills Cancer - Life Enthusiast Thread starter bossman523; Start date May 8, 2013; bossman523 Banned. of Estrogen Metabolism Harini S. Aiyer1 and Ramesh C. Gupta1,2 Abstract To determine whether dietary berries and ellagic acid prevent 17-estradiol (E 2)-induced mammary tumors by altering estrogen metabolism, we randomized August-Copenhagen Irish rats (n = 6 per group) into five groups: sham implant + control diet, E 2 implant + control . Detoxification of Estrogen: Environment, Genetics & Nutritional Showing the single result . Moreover, ellagic acid induced nodule mineralization in an osteoblastic cell line (KS483), an effect that was abolished by the estrogen antagonist. What Is Ellagic Acid? 10 Foods That Contain Ellagic Acid Ellagic acid is a polyphenol derived from plants that interact with estrogen receptors ER and ER subtype that shows estrogenic/antiestrogenic activity and can act to protect against cancer, inflammation, heart disease, and osteoporosis. 2008;60(2):227-34. In fact, ellagic acid has been shown to inhibit breast cancer development in a variety of cell and animal studies, in part by inhibiting angiogenesis. Ellagic acid is a plant-derived polyphenol, possessing antioxidant, antiproliferative, and antiatherogenic properties. An interesting work investigated the effects of RIE on female chloasma. Abstract Title: Berries and ellagic acid prevent estrogen-induced mammary tumorigenesis by modulating enzymes of estrogen metabolism. The mushroom has many helpful compounds, of which EA is the highest. Aromatase plays a key role in breast carcinogenesis; therefore, the growth of breast cancer is . Ellagic acid effects on testis, sex hormones, oxidative stress, and Female ACI rats (8-9 wk) were fed either AIN-93M diet (n = 25) or diet supplemented with either powdered blueberry (n = 19) and black raspberry (n = 19) at 2.5% wt/wt each or ellagic acid (n = 22) at 400 ppm. Nutr Cancer. alpha+beta+ transcript in estrogen receptor-positive MCF-7 breast cancer cells. . This renders the model more useful for chemopreventive interventions with translational value. The present study aimed to evaluate the effects of ellagic acid on testicular tissue changes, sexual hormones, antioxidant defense system, and caspase-9 and Bcl2 gene expression in the busulfan-induced relative sterile rat model. Effect of ellagic acid on the expression of human telomerase reverse Pomegranate for Building Strength - T NATION 3, 727-737 (2010). 0021-8561 Subject: mineralization, pomegranates, humans, hormone receptors, ellagic acid, osteoblasts, estrogenic properties, cell lines, breast neoplasms Excess estradiol in men can cause benign prostatic hyperplasia, gynecomastia . Aiyer HS, Kichambare S, Gupta RC. Cancer Prev Res (Phila). The antioxidants they contain, such as vitamin C, gallic acid, ellagic acid, and various polyphenols, can help reduce inflammation. Ellagic acid is a powerful antioxidant in many foods. Ellagic Acid: A Review on Its Natural Sources, Chemical - Hindawi Blueberries and Cancer, Increase Antioxidant Activity - AICR 2267 Elevated levels of estrogen are associated with higher risk for breast cancer. Beefsteak Fungus. Evaluation of Estrogenic/Antiestrogenic Activity of Ellagic Acid via Ellagic Acid, Kaempferol, and Quercetin from - SpringerLink Buy Ellagic Acid Supplements - support for cancer PDF Asian Journal of Phytomedicine and Clinical Research Ellagic acid is used for cancer, dark skin patches on the face (melasma), memory and thinking skills (cognitive function), diabetes, and many other purposes, but there is no good scientific . . Research in the past decade confirms that ellagic acid markedly inhibits the ability of other chemicals to cause mutations in bacteria. Plant foods contain thousands of natural chemicals. 9 Intriguing Health Benefits of Chestnuts In addition, it shows anticarcinogenic, antifibrotic, antiplasmodial, apoptotic, and chemopreventive activities as well. This is potentially good news for women: The ACS reports that ellagic acid may reduce the effect of estrogen in promoting the growth of breast cancer cells. Punica granatum (P. granatum) is a fruit-bearing tree from the Punicaceae family, indigenous to Iran. Ellagic acid found in pomegranates inhibits aromatase, an enzyme that converts androgen to estrogen. In laboratory studies, ellagic acid showed antiviral, antibacterial and . Design and methods. Pomegranate Ellagitannin-Derived Compounds Exhibit Anti-proliferative GreenMedInfo Summary. PDF Berries and Ellagic Acid Prevent Estrogen-Induced Mammary Tumorigenesis Further evaluation revealed that ellagic acid was a potent antiestrogen in MCF-7 breast cancer-derived cells, increasing, like the pure estrogen antagonist ICI182780, IGFBP-3 levels. Estrogen overload can be problematic for a number of reasons. Ellagic acid seems to have some particular anti-cancer properties. Cancer Prev. Evaluation of estrogenic/antiestrogenic activity of ellagic acid via . . On consumption, pomegranate ETs hydrolyze, releasing ellagic acid (EA) which is then converted to 3,8-dihydroxy-6H-dibenzo[b,d]pyran . Ellagic acid has also been found to be effective in the prevention of estrogen-induced mammary tumors in rats. Amazon.com: [EdenLife] Korean Beauty Anti-ageing EdenFoodFarm ELLAGIC ACID - Uses, Side Effects, and More - WebMD Apart from its growth stimulatory effects, estrogen is also . PubMed journal article: Berries and ellagic acid prevent estrogen-induced mammary tumorigenesis by modulating enzymes of estrogen metabolism. . Female ACI rats (8-9 wk) were fed either AIN-93M diet (n = 25) or diet supplemented with either powdered blueberry (n = 19) and black raspberry (n = 19) at 2.5% wt/wt each or ellagic acid (n = 22) at 400 ppm. Ellagic acid (EA) is a bioactive polyphenolic compound naturally occurring as secondary metabolite in many plant taxa. What Is Ellagic Acid? | Benefits and More - Ben's Natural Health Three time pointsearly (6 wk), intermediate (18 wk), and late (24 wk)were chosen, and the . Other berries that are rich in ellagic acid include cranberries and cloudberries. 2010;3(6):727-737. View at . One food that contains ellagic acid is the beefsteak fungus. Ellagic acid also reportedly can help the liver break down or remove cancer-causing agents from the blood. They neutralize free radicals, which are key drivers of chronic . Contains aboundant nutrients frim pomegranate (vitamin B C, ellagic acid, estrogen, polyphenol, anthocyanin, citric acid, folic acid, calcium, potassium, zinc, etc.). Ellagic acid was selected based on >95% inhibition of 8-oxodeoxyguosine (8-oxodG) and other unidentified oxidative DNA adducts induced by 4-hydroxy-17-estradiol and CuCl2 in vitro. . In addition, research has found that it has antibacterial and antiviral properties. Whether this compound has estrogenic/antiestrogenic activity, however, remains largely unknown. Endometrium . Berries and ellagic acid prevent estrogen-induced mammary tumorigenesis Name. Ellagic Acid: To Oncologists - life-enthusiast.com In this study, we investigated efficacy of dietary berries and ellagic acid to reduce estrogen-mediated mammary tumorigenesis. Read free for 30 days Ellagic Acid. Ellagic Acid - Read online for free. 17-estradiol and ICI182780, a known estrogen antagonist, served as positive and negative controls respectively. 20, pp. "Evaluation of estrogenic/antiestrogenic activity of ellagic acid via the estrogen receptor subtypes ERalpha and ERbeta," Journal of Agricultural and Food Chemistry, vol. 6. According to the research conducted by Wang et al. Awards 0. Ellagic acid also suppresses the expression of cyclooxygenase 2 and inducible nitric oxide synthase via the inhibition of nuclear factor-kappa B (NF-B) activity in several normal and cancer cells (8,9). Fourth, ellagic acid helps prevent cancer, birth defects, etc. While officially indicated for women, this drug has proven effective in the off-label use of reducing estrogens (in particular and more importantly, estradiol) in men. . Evaluation of Estrogenic/Antiestrogenic Activity of Ellagic Acid via . To determine whether dietary berries and ellagic acid prevent 17beta-estradiol (E(2))-induced mammary tumors by altering estrogen metabolism, we . Raspberries are one of the few sources of ellagitannins that your body can transform into useful levels of ellagic acid. It is revealed that ellagic acid was a potent antiestrogen in MCF-7 breast cancer-derived cells, increasing, like the pure estrogen antagonist ICI182780, IGFBP-3 levels. The aromatase enzyme, which converts androgen to estrogen, plays a key role in breast carcinogenesis. Ellagic acid dosage ranges from 200mg to 500mg per day. Effects of Black Raspberries and Their Ellagic Acid and Anthocyanin (PDF) Berries and Ellagic Acid Prevent Estrogen-Induced Mammary Berries and ellagic acid prevent estrogen-induced mammary tumorigenesis Ellagic Acid has the ability to inhibit mutations within a cell's DNA, causing apoptosis (normal death) in cancer cells. Berries and ellagic acid prevent estrogen-induced mammary tumorigenesis by modulating enzymes of estrogen metabolism. Phytoestrogens. The administration of Ellagic acid, Kaempferol, and Quercetin as combined drug via the novel drug delivery systems will be a valuable therapeutic choice for the . Ellagic Acid | Nf b | Estrogen Download Prime PubMed App to iPhone, iPad, or Android. Endometrium . Determining the effect of ellagic acid on the proliferation and Fifth, ellagic acid seems to have anti-viral and anti-carcinogenic effects. Anticancer DNA Repair Apoptosis Life Extension - NutriMedical Ellagic acid | C14H6O8 - PubChem In addition, a previous report claimed that ellagic acid is a natural selective estrogen receptor modulator (Papoutsi et al., 2005). 1 Punicalagin/urolithin blocks the conversion of testosterone to estrogen. It can clearly act as an anti-oxidant, and has been found, in several instances, to cause cell death (apoptosis) in cancer cells in laboratory experiments. Evaluation of estrogenic/antiestrogenic activity of ellagic acid via MicroRNA 'signature' during estrogen-mediated mammary carcinogenesis Ellagic acid hydrate | C14H8O9 - PubChem Dietary berries and ellagic acid diminish estrogen-mediated mammary Natural compounds in pomegranates may prevent growth of hormone Moreover, ellagic acid induced nodule mineralization in an osteoblastic cell line (KS483), an effect that was abolished by the estrogen antagonist. In other laboratory studies, ellagic acid seems to reduce the effect of estrogen hormone in women in promoting growth of . This results in less testosterone being converted to DHT, thereby . To answer this question, we first investigated the ability of ellagic acid to influence the activity of the estrogen receptor . In this study, we investigated efcacy of dietary berries and ellagic acidtoreduceestrogen-mediatedmammarytumorigenesis.Female ACI rats (8-9 wk) were fed either AIN-93M diet (n = 25) or diet supplemented with either powdered blueberry (n = 19) and black raspberry (n = 19) at 2.5% wt/wt each or ellagic acid (n = 22) at 400 ppm. Whether this compound has estrogenic/antiestrogenic activity, however, remains largely unknown. First, ellagic acid kills cancer cells by promoting cell death (apoptosis). Ellagic Acid May Be a Natural SERM | Osteoporosis-Studies Pomegranate juice fermented by tannin acyl hydrolase and Lactobacillus Glucosinolates. Ellagic acid, Kaempferol, and Quercetin were the best A. nilotica's phytochemical constituents that contribute to the therapeutic activities, were non-toxic as well as non-carcinogen. Ellagic Acid | Osteoporosis-Studies Further evaluation revealed that ellagic acid was a potent antiestrogen in MCF-7 breast cancer-derived cells, increasing, like the pure estrogen antagonist ICI182780, IGFBP-3 levels. In order to determine whether berries and ellagic acid affect estrogen metabolism, we examined the regulation of gene expression of key enzymes involved in estrogen metabolism and signaling, in the mammary tissue during the course of mammary tumorigenesis. Edderkaoui M, Odinokova I . To determine whether dietary berries and ellagic acid prevent 17beta-estradiol (E(2))-induced mammary tumors by altering estrogen metabolism, we randomized Aug Estrogen stimulates the proliferation of breast cancer cells and the growth of estrogen-responsive tumors. Ellagic acid found in pomegranates inhibits aromatase, an enzyme that converts androgen to estrogen. These materials are considered a selective estrogen By using our site, you agree to our collection of information through the use of . Ellagic Acid - Bodybuilding.com Forums Ellagic acid, a polyphenol, occurs predominantly as ellagitannins in fruits, vegetables, and some plant foods [1,2].Ellagic acid has antioxidant, antimutagenic, and anticancer properties; but the low level of ellagic acid in tissue and plasma limits its bioavailability [3,4,5,6].Fortunately, some of the unabsorbed ellagic acid is metabolized by the intestinal microbiota of animals or humans to . Dietary berries and ellagic acid diminish estrogen-mediated mammary tumorigenesis in ACI rats Harini S Aiyer, Cidambi Srinivasan, Ramesh C Gupta Nutr Cancer . Animal studies suggested that only a limited fraction of ellagic acid was orally bioavailable. [PDF] Dietary Berries and Ellagic Acid Diminish Estrogen-Mediated Estrogen dominance is a term that has been used to describe the overload of estrogen.